Reproduction Abstracts

Introduction: The regulation of follicle development is not well understood, despite its importance in determining fertility, but there is evidence that the oocyte plays a key role. The female C1galt1 Mutant mouse has an oocyte-specific deletion of the T-synthase enzyme and as a result cannot synthesise core 1-derived O-glycans. Mutant females exhibit a phenotype of increased fertility and altered follicle development. To investigate the hypothesis that changes in the developm...